The normal intima occurs independently of and prior to the fat feeding associated with atherosclerosis 4. Table 1. Mural cells, cell types that make up arterial wall coats around the endothelium. Normal intima versus neointima As we have just discussed, intimal cell masses form spontaneously at specific sites in the intima of humans and other large animals 4 , Genetic versus epigenetic changes Of course, neoplasia implies a genetic origin, a mutation as is believed to be the cause of uterine leiomyomas 12 , 13 , 16 , 20 , — Figure 2. Clonality is normal. Clonality in the immune system Surprisingly, a recent report shows that clonality of leukopoietic lineages in bone marrow is relevant to the final events in atherosclerosis Figure 3.
Omnis cellula e cellula. Figure 4. Cell type and cell phenotype are not necessarily the same thing.
Animal Models of Cardiovascular Disease | Revista Española de Cardiología
Figure 5. A new definition of cell type The definition of cell types has traditionally been based on marker genes that is, proteins found at high levels in a differentiated tissue. Figure 6. Defining cell type by cluster: three types and seven types? Figure 7. Endothelial cell precursors can be identified by lineage tracing within the proepicardial organ before cells from that precursor migrate to form the epicardium. Possible sources other than mural cells for origins of intimal cells The media is not the only possible source for intimal cells.
Figure 8. Layers of the artery wall. Figure 9. Dichotomous origins of medial smooth muscle and adventitial fibroblasts. An intimal hypothesis based on fenestrae Figure 10 proposes perhaps the simplest model for plaque monoclonality.
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Figure The simplest hypothesis. In the end, does intimal clonality matter? Our review has tried to make seven points: 1. Grant information Mark W. F recommended References 1.
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